Since highly active anti-retroviral drug
therapy was made available to people infected with HIV living in developing
countries, the HIV death rate has dropped in the first five years after infection
to the point where it is equal to the normal death rates in the developing
countries, a new report found.
“Our results show the progress in reducing
mortality among HIV-infected individuals toward the levels experienced by the
general uninfected population,” the researchers led by Kholoud Porter and
Krishnan Bhaskaran of the Medical Research Council Clinical Trials Unit of London
said.
The findings are based on monitoring 16,534
HIV-infected individuals between 1981 and 2006. With the use of highly active
anti-retroviral therapy (HAART), which uses multiple anti-retroviral drug “cocktails,”
there has been a decline in the first five year mortality to the same level of
the uninfected population. Researchers estimated an 88 percent reduction in
excess mortality in 200-2001 compared with the period before 1996.
By 2006,
researchers said, “there was no evidence of any excess mortality to five years”
among people infected with HIV/AIDS. The risk raises after five years of the infection,
possible because people are less able to tolerate the drugs, researchers said. For
people over 45, the raised risk was 5 percent at 10 years and 12 percent at 15
years. A higher risk of excess mortality was associated with older age and higher
exposure to injection drug use.
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