According to results from two large international studies,
patients with relapsed or refractory multiple myeloma, a cancer of the cells in
the bone marrow that make blood, who were treated with Revlimid (lenalidomide)
and dexamethasone had significantly improved progression-free and overall
survival compared with patients treated with dexamethasone and placebo.
Both the studies showed that patients treated with the lenalidomide and
dexamethasone had an overall response rate of over 60 per cent compared with
around 20 per cent for patients on the dexamethasone and placebo arm. Also,
results showed that patients on the combination drug arm had a 30 per cent
greater overall survival and more than twice the time to progression of the
dexamethasone and placebo patients.
Lenalidomide is a more potent analogue of thalidomide and is marketed as
Revlimid, by the Celgene Corporation. It belongs to a class of drugs known as
immunomodulatory agents because they change the way the immune system works.
The drug has attracted attention because it's part of a new
range of therapies that has dramatically changed quality of life for myeloma
patients. It's an oral drug that can be taken at home, and it does not have the
difficult side effects of conventional chemotherapies because it directly
targets cancer cells and the processes that help them grow.
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